New Genetic Research Investigates the Link between Inflammation and Macular Degeneration

European researchers investigating the link between inflammation and age-related macular degeneration (AMD) have identified a protein, called FHL-1, that functions as a type of “regulator” to protect the eye from an attack by the immune system. According to lead author Dr. Simon Clark, this important genetic research has identified a new target for therapeutic drugs … Continued

Is Glaucoma a Genetic Disease? Three New Research Projects Pinpoint Six Specific Genes

Three new research projects exploring the role of genes – and six genes in particular – as possible causes of glaucoma have been published simultaneously in the August 31, 2014 online edition of Nature Genetics. Nature Publishing Group (NPG) is a publisher of scientific and medical information in print and online. NPG publishes a range … Continued

Can Gene Therapy Provide a Cure for Retinal Disease? An Early-Stage Clinical Trial Says “Maybe”

A group of international researchers from the United Kingdom, the United States, the Netherlands, and Portugal have used gene therapy in a clinical trial to treat a small group of male subjects with choroideremia, a rare degenerative eye disease. This early-stage clinical trial demonstrates potential for the use of gene therapy to treat a number … Continued

Could the Loss of an Anti-Aging Gene Contribute to Wet and Dry Macular Degeneration?

A team of researchers has determined that the loss of a particular anti-aging, or aging-suppressor, gene – known as Klotho protein (KL) – induces retinal deterioration in mice and may contribute to both wet and dry age-related macular degeneration (AMD). The KL gene helps to protect against oxidative stress, which causes dry AMD, and inhibits … Continued

Gene Therapy and Leber Congenital Amaurosis: Update from the National Eye Institute

The following update addressing the role of gene therapy in the treatment of Leber congenital amaurosis (LCA), an inherited and progressive eye disease, is adapted, with permission, from a National Eye Institute news brief entitled New Findings Suggest Need for Combined Strategy in Treatment of Rare Form of Blindness. The mission of the National Eye … Continued

A Nationwide Study Is Investigating Genetic and Other Risk Factors for Macular Degeneration

Researchers at the Jules Stein Eye Institute of the University of California at Los Angeles are continuing to recruit participants for a nationwide study investigating the heredity and exposure risk factors that lead to the development of age-related macular degeneration. The GARM II Study The goal of the Genetics of Age-Related Maculopathy (GARM II) Study … Continued