Which Real-Life Factors Influence Adherence to Lucentis Treatment for Macular Degeneration?

A recent study, published in Graefe’s Archive for Clinical and Experimental Ophthalmology, has attempted to “identify factors and problems influencing treatment adherence in patients undergoing anti-VEGF therapy for neovascular age-related macular degeneration under real-life conditions.” Graefe’s Archive is an international journal that presents original clinical reports and experimental studies by ophthalmologists and vision research scientists … Continued

My Journey into Ophthalmology by Guest Blogger Irv Arons

Guest blogger Irv Arons is the creator of – and driving force behind – Irv Arons’ Journal, an online compendium of the latest information on ophthalmics, medical lasers, and new drugs and devices for the treatment of age-related macular degeneration (AMD). Until his retirement in 2005, Irv was a consultant to the ophthalmic industry for … Continued

Using Microneedles To Deliver Drugs to the Retina: Helpful for Macular Degeneration?

Using a Microneedle for Drug Delivery to the Posterior Segment of the Eye was published in the July 2012 issue of Investigative Ophthalmology & Visual Science, the official journal of the Association for Research in Vision and Ophthalmology (ARVO). ARVO is an international organization that encourages and assists research, training, publication, and dissemination of knowledge … Continued

Avastin and Lucentis for Macular Degeneration: Head-to-Head Once Again

Year Two results from the Comparison of Age-Related Macular Degeneration (AMD) Treatments Trials (CATT) that evaluated the effectiveness of Avastin (bevacizumab) versus Lucentis (ranibizumab) in a head-to-head clinical trial are now available. CATT is a multi-center, prospective clinical trial, funded by the National Eye Institute (NEI), a component agency of the National Institutes of Health. … Continued

Avastin and Lucentis: Cardiovascular Risks? A New Canadian Study Says No

Last week, I read yet another intriguing research study regarding the age-related macular degeneration (AMD) drugs Lucentis and Avastin. The newly-released Canadian study investigated the risk of cardiovascular events [i.e., heart attack, congestive heart failure, blood clotting, and stroke] in patients who were receiving either Avastin or Lucentis injections for retinal disease. I’ve blogged about … Continued

FDA Approves EYLEA™ for the Treatment of Wet Macular Degeneration

Anatomy of the EYLEA™ Drug Approval Process In February 2011, Regeneron Pharmaceuticals, Inc. announced that the company had submitted a Biologics License Application (BLA) to the United States Food and Drug Administration (FDA) for Regeneron’s VEGF Trap-Eye (now called EYLEA™), a potential injectable drug treatment for wet age-related macular degeneration (AMD). The FDA next announced … Continued

A New Clinical Trial for Patients Who Do not Respond to Lucentis or Avastin for Macular Degeneration

This week, I learned about a new clinical trial for a drug that shows promise in the treatment of wet macular degeneration (AMD) in patients who have not responded to treatment with either Avastin or Lucentis, the two drug interventions most commonly used at present. The drug is called iSONEP™ and it has been created … Continued

Could Avastin and Lucentis Trigger Elevated Eye Pressure?

The August 2011 issue of the British Journal of Ophthalmology contains an article that caught my attention. In the article, entitled Sustained elevation of intraocular pressure after intravitreal injections of anti-VEGF agents (Translation: Sustained high pressure within the eye after injection with Avastin or Lucentis), the authors investigated several critical issues surrounding the longer-term safety … Continued